The first set of wards encountered upon ascending to the second floor are the regular wards. These wards were used for patients that were considered low-risk, and as a result these rooms could be considered small but adequate. In each room, a metal bed frame, an end table, and a shelf for books can be found in various states of decay and with various objects on them, left largely untouched as a result of the abandonment of the island. Nothing about the rooms is comforting, however; like most of the asylum they were built with an eye towards cost efficiency rather than patient comfort. Belongings of previous patients can still be found in these rooms—a visible reminder of what the asylum used to be used for, with pictures from art therapy stuck up on some walls and photos of family on others.

Deeper into the second floor, the Intensive Care Wards can be found. These rooms were used to house patients who were deemed to require more concentrated and in-depth care than the low-risk patients, but who weren't considered a serious risk to themselves or others. Still, to prevent any chance of injury, a metal cot topped with a mattress is the only furniture in each room and bars block direct access to the windows. The rooms themselves showing varying signs of the patients that once lived within them. One in particular has scratch marks up and down the walls.

The most secluded and most secure of the second floor wards, solitary confinement is where patients who had been given up on were kept. Each padded cell would be used to contain a single high-risk patient. These patients would be cared for in that they would be given food and water, but beyond that they were left largely to their own devices. The corridor leading to the solitary unit has two gates down intersecting its length to ensure no one gets out, although both of these have been left unsecured (and, in the case of the second one, rusted away). The ward itself is sparse, with only a few gurneys and straitjackets left lying around. Heavy metal doors lead into each individual cell which can be bolted from the outside, however many of these bolts have rusted away or are flimsy enough that they're liable to break off in someone's hand.